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Probiotics are live microorganisms that provide health benefits when consumed, typically by improving or restoring gut flora. Probiotics are known to provide various health benefits, such as balancing the digestive system, improving mental health disorders, lowering cholesterol levels, and enhancing overall immunity. They also aid in lowering symptoms of gastrointestinal (GI) diseases, such as yeast infections, diarrhea, irritable bowel syndrome, eczema, lactose intolerance, urinary tract infection, and constipation.1
Probiotics have been used in the dental field to repopulate the oral cavity with good bacteria after periodontal debridement of periodontal pathogens.2 They have also been used to treat patients with halitosis, black hairy tongue, thrush (candida), and/or high cavity rates.3 Despite their positive health outcomes, if overused and/or misused, the risks of probiotics can outweigh their benefits.
The overuse and indiscriminate administration of probiotics have reached epidemic proportions. The global probiotic market size has reached $57.1 billion in 2023 and is assessed to grow at a compounded annual growth rate of 8.7% from 2024 to 2032. By the end of 2032, the probiotic consumer market is expected to exceed $91.4 billion.4
The adage too much of a good thing is a bad thing holds true with probiotic use. Unfortunately, simply taking a probiotic without direction or without knowing what bacteria you are deficient in can cause systemic problems.
For example, one type of bacteria commonly found in over-the-counter probiotics, Lactobacillus, has been associated with an increase in D-lactic acid and has caused SIBO (small intestinal bowel overgrowth) in certain patients.
Other studies have shown that overreliance on probiotics can cause brain fog, poor concentration, short-term memory problems, and metabolic acidosis.5 The authors of this study concluded that probiotics should contain strains of bacteria that are patient-specific and should be treated like a medication, not a supplement.
Although there are numerous brands of probiotic supplements (figure 1), many contain a limited number of bacterial strains, primarily from the groups Lactobacillus, Bifidobacterium, and a few others. Patients who take probiotics without knowing which strains they need can do more harm than good.
For instance, concentrated doses of a few strains of bacteria (e.g., Lactobacillus casei) can upset the balance in the gut inadvertently by creating a form of dysbiosis that comes from having too much of a good bacterium, which decreases the more important factor of microbiome diversity.
Directed probiotic use should include oral saliva and stool testing. This will determine the patient’s oral and gut microbiome and ascertain what bacteria strains are or are not needed (figure 2). Based on this information, the clinician can then determine what, if any, probiotic is needed and how it needs to change over time to support the evolving microbial flora. In other words, one type of probiotic should not be taken ad infinitum, and focus should be placed on increasing the diversity of microbial flora.
Note: This article originally appeared in Perio-Implant Advisory, a chairside resource for dentists and hygienists that focuses on periodontal-and implant-related issues.
Brigitte Rizzo, NP, is a nurse practitioner who graduated with honors from the State University of New York at Stony Brook, School of Medicine in 2002, and has been practicing internal medicine for more than 20 years. She has multiple certifications in the integrative wellness field with licenses in multiple states. She is currently in private practice at Meraki Integrative and Wellness and is cofounder of the Metatron Miracles Recovery and Rehab Center in Naples, Florida.
Scott Froum, DDS (Editorial Director), a graduate of the State University of New York, Stony Brook School of Dental Medicine, is a periodontist in private practice at 1110 2nd Avenue, Suite 305, New York City, New York. He is the editorial director of Perio-Implant Advisory and serves on the editorial advisory board of Dental Economics. Dr. Froum, a diplomate of both the American Academy of Periodontology and the American Academy of Osseointegration, is a volunteer professor in the postgraduate periodontal program at SUNY Stony Brook School of Dental Medicine. He is a PhD candidate in the field of functional and integrative nutrition. Contact him through his website at drscottfroum.com or (212) 751-8530.
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